Current Studies

Randomized Controlled Trials

The Harmonized Interventions to Maintain health via Appropriate risk factor modification and Lifestyle changes in Adolescent and Young Adult cancer Survivors (HIMALAYAS) trial 

  • Nominated Principal Investigator: Thavendiranathan, D.
  • Co-Principal Investigators: Abdel-Qadir, H., Adams, S.C., Awadalla, P., Charpentier, D., Davis, M., Gyenes, G., Goddard, K., Gupta, A., Hayami, D., Hodgson, D., Lau, B., Oh, P., Paterson, I., Pituskin, E., & Tournoux, F.
  • Co-Investigators: Brezden-Masley, C., Cifra, B., Cooks, B., Dore, I., Gauvin, L., Grandy, S., Ivers, N., Kirkham, A., Lega, I., McKillop, S., Mulvagh, S., Nadler, M., Nathan, P., Price, J., Rac, V.,  Rayson, D., Ribeiro, P., Sabiston, C.M., Samouelian, V., Santa Mina, D., Spavor, M., Thorpe, K. & Tomlinson, G.
  • Fellows & Trainees: Bonsignore, A., Brahmbhatt, P., Calvillo-Arguelles, Lee, L. & Rivera Theurel, F.
  • Design: Multi-centre randomized controlled trial
  • Funding: Canadian Cancer Society; Canadian Institutes of Health Research
  • Status: REB Approved

The Harmonized Interventions to Maintain health via Appropriate risk factor modification and Lifestyle changes in Adolescent and Young Adult cancer Survivors (HIMALAYAS) pilot study 

  • Principal Investigators: Thavendiranathan, D., Hodgson, D., Oh, P., Abdel-Qadir, H. & Adams, S.C. 
  • Co-Investigators: Gupta, A., Nathan, P., Awadalla, P., Santa Mina, D., Sabiston, C.M., Brezden-Masley, C., Cifra, B., Lega, I., Price, J., Ross, H., Cafazzo, J., Duhamel, J., Woo, A., Rac, V. & Ivers, N. 
  • Design: Randomized controlled feasibility trial
  • Funding: Peter Munk Cardiac Centre Innovation Fund; MSH-UHN AMO Innovation Fund
  • Status: REB Approved

The Prehabilitation to Improve Cancer Surgery Outcomes in newly diagnosed adolescent and young adult Extremity Sarcoma patients (PICaSO-ES) trial

  • Investigators: Adams, S.C. (Co-PI), Chen, M., Gupta, A., Wunder, J., Ferguson, P., D’Agostino, N., Mitchell, L., Sabiston, C.M., Griffin, A., Govindarajan, A. & Santa Mina, D. (Co-PI)
  • Design: Randomized controlled feasibility trial
  • Funding: Michael Kamin Heart Award in AYA Oncology / Princess Margaret AYA Oncology Program
  • Status: Restarting

Prospective Cohort Studies

Observational Cohorts

Precision cardiorespiratory disease profiling & risk prediction in survivors of lymphomas & breast cancer (PROGRESS-LBC): A pilot prospective cohort study

  • Investigators: Adams, S.C. (PI), Paaladinesh Thavendiranathan (co-PI), Husam Abdel-Qadir (co-PI), Eita Amir, Barbara Cifra, Heather Edgell, Jason Fish, John Floras, Jenna Gillen, Abha Gupta, Iliana Lega, Luc Mertens, Yas Moyedi, Paul Nathan, Paul Oh, Heather Ross, Catherine Sabiston, Daniel Santa Mina, Linda Trinh; Fellows: Leanna Lee, Fernando Rivera Theurel; Trainees: Priya Brahmbhatt, Dakota Gustafson, Marc Sicova
  • Design: Prospective pilot observational study
  • Funding: Investigator initiated
  • Status: REB Application

Precision cardiorespiratory disease profiling & risk prediction in survivors of pediatric cancers (PROGRESS-PC): A pilot prospective cohort study

  • Investigators: Adams, S.C. (PI), Paaladinesh Thavendiranathan (co-PI), Husam Abdel-Qadir (co-PI), Eita Amir, Barbara Cifra, Heather Edgell, Jason Fish, John Floras, Jenna Gillen, Abha Gupta, Iliana Lega, Luc Mertens, Yas Moyedi, Paul Nathan, Paul Oh, Heather Ross, Catherine Sabiston, Daniel Santa Mina, Linda Trinh; Fellows: Leanna Lee, Fernando Rivera Theurel; Trainees: Priya Brahmbhatt, Dakota Gustafson, Marc Sicova
  • Design: Prospective pilot observational study
  • Funding: Investigator initiated
  • Status: REB Application

Intervention Cohorts

The Rural Exercise for Cancer Patients and Survivors (RECaPS) project

  • Investigators: Adams, S.C. (Research Lead), Smith-Turchyn, J., Dempster, H., Trenholm, R., Lavigne, D., Allen, L., Hailstone, K., Sabiston, C.M., Santa Mina, D. & MacMillan, L. (PI)
  • Design: Single arm feasibility cohort study
  • Funding: Northern Ontario Academic Medical Association / Northern Ontario School of Medicine
  • Status: Restarting 

Cross-Sectional Survey Studies

No studies ongoing

  • Investigators: N/A
  • Design: N/A
  • Funding: N/A
  • Status: N/A

Select Publications

randomized controlled trials

Citation: Adams SC, DeLorey DS, Davenport MH, et al: Effects of high-intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: A phase 2 randomized controlled trial. Cancer 123:4057-4065, 2017

Citation: Adams SC, Segal RJ, McKenzie DC, et al: Impact of resistance and aerobic exercise on sarcopenia and dynapenia in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. Breast Cancer Res Treat 158:497-507, 2016

Citation: Adams SC, DeLorey DS, Davenport MH, et al: Effects of high-intensity interval training on fatigue and quality of life in testicular cancer survivors. Br J Cancer 118:1313-1321, 2018

prospective & retrospective observational studies

Citation: Scott JM, Li N, Liu Q, et al: Association of exercise with mortality in adult survivors of childhood cancer. JAMA Oncol 4:1352-1358, 2018

Citation: Bonsignore A, Marwick TH, Adams SC, et al: Clinical, Echocardiographic, and Biomarker Associations With Impaired Cardiorespiratory Fitness Early After HER2+ Breast Cancer Therapy. JACC: CardioOncology, 2021

Citation: Adams SC, Schondorf R, Benoit J, et al: Impact of cancer and chemotherapy on autonomic nervous system function and cardiovascular reactivity in young adults with cancer: a case-controlled feasibility study. BMC Cancer 15:414, 2015

cross-sectional studies

Citation: Adams SC, Petrella A, Sabiston CM, et al: Preferences for exercise and physical activity support in adolescent and young adult cancer survivors: a cross-sectional survey. Support Care Cancer 29:4113-4127, 2021

Citation: Adams SC, Smith-Turchyn J, Santa Mina D, et al: The Exercise Oncology Knowledge Mobilization Initiative: An international modified delphi study. Front Oncol 11:713199, 2021

Citation: Smith-Turchyn J, Allen L, Dart J, et al: Characterizing the exercise behaviour, preferences, barriers, and facilitators of cancer survivors in a rural Canadian community: A cross-sectional survey. Current Oncology 28:3172-3187, 2021

systematic reviews & meta-analyses

Citation: Adams SC, McMillan J, Salline K, et al: Comparing the reporting and conduct quality of exercise and pharmacological randomised controlled trials: a systematic review. BMJ Open 11:e048218, 2021

Citation: Scott JM, Zabor EC, Schwitzer E, et al: Efficacy of exercise therapy on cardiorespiratory fitness in patients with cancer: A systematic review and meta-analysis. J Clin Oncol 36:2297-2305, 2018

reviews, commentaries & correspondence

Citation: Scott JM, Adams SC, Koelwyn GJ, et al: Cardiovascular late effects and exercise treatment in breast cancer: Current evidence and future directions. Can J Cardiol 32:881-90, 2016

Citation: Adams SC, Herman J, Lega IC, et al: Young adult cancer survivorship: Recommendations for patient follow-up, exercise therapy, and research. JNCI Cancer Spectr 5:pkaa099, 2021

Citation: Adams SC, Iyengar NM, Scott JM, et al: Exercise implementation in oncology: one size does not fit all. J Clin Oncol 36:925-926, 2018

Citation: Santa Mina D, Langelier D, Adams SC, et al: Exercise as part of routine cancer care. The Lancet Oncology 19:e433-e436, 2018